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Abstract Hepatocellular carcinoma HCC is a cause of several deaths related to cancer worldwidely. However, the disease is detected in advanced stage; moreover some available therapies are restricted to palliative care and local treatment. MicroRNAs can regulate important pathways on carcinogenesis, as tumor angiogenesis and progression. So, they can be considered as possible markers of prognosis in HCC, and therapeutic target for this tumor type. In this review, we discuss the recent advances related to the cause highlighting the main risk factors , treatment, biomarkers, clinic aspects, and outcome in hepatocellular carcinoma.

Mol Cell Biol. Benn J, Schneider RJ. Hepatitis B virus HBx protein activates The association between Hepatitis B virus X diabetes and hepatocellular carcinoma: Clin Gastroenterol Hepatol. Erk associates Nonalcoholic steato- with and primes GSK-3beta for its inactivation resulting in hepatitis: Mol Cell. Hepatitis B Pathogenesis of non-alcoholic virus X protein represses E-cadherin expression via activation steatohepatitis: Clin Liver Dis. Aflatoxin Enhanced cell exposure, hepatitis B virus infection and liver cancer in survival of Hep3B cells by the hepatitis B x antigen effector, Swaziland.

URG11, is associated with upregulation of beta-catenin. Nelson WJ, Nusse R. Convergence of Wnt, beta-catenin, and carcinomas. Selective G to T Hepatitis B virus-related insertional mutagenesis in target.

Curr Cancer Drug Targets. Bioch Biophys Acta. Hum Mutat. Transcriptional repression of the human C, Lagorce D, et al. Hepatitis B virus-related insertional Moon E-J. Hepatitis B virus X protein induces angiogenesis recurrently targets human telomerase gene.

Hepatitis B virus Human hepatitis B virus X protein is a possible mediator Nature.

D, et al. Identification of human cancer-related genes by Molecular viral Murakami S.

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Hepatitis B virus X protein: J Gastroenterol. Hepatitis B virus-related Direct interaction of hepatocarcinogenesis: Viral hepatocarcinogenesis.

J Virol. Andrisani OM, Barnabas S. The transcriptional function of the Cathomas G, et al. Beta-catenin mutations are frequent in hepatitis B virus X protein and its role in hepatocarcinogenesis human hepatocellular carcinomas associated with hepatitis review. Int J Oncol. C virus infection. Am J Pathol.

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Transforming growth factor-beta signaling M, et al. Hepato- to microenvironmental components of chronic inflammatory logy.

Principios Basicos Da Musica Para Juventude Maria Luiza de Matos Priolli

Cancer Res. The role of nitric oxide in Lala PK, Chakraborty C. Role of nitric oxide in carcinogenesis carcinoma. Lancet Oncol. Prognostic staging system for Transcriptional regulation of human tions, and a proposal for a new staging system, the Japan inducible nitric oxide synthase NOS2 gene by cytokines: Proc Natl Acad Sci USA.

Non-viral causes of Construction of the Chinese University Prognostic Index for hepatocellular carcinoma. World J Gastroenterol. N, Hasegawa H, et al. Natural history of hepatocellular Okuda K.

Natural history of hepatocellular carcinoma Bruix J, Sherman M. Management of hepatocellular including fibrolamellar and hepato-cholangiocarcinoma carcinoma. J Gastroenterol Hepatol. Theise ND.

Macroregenerative dysplastic nodules and A new prognostic system for hepatocellular carcinoma: Macroregenerative Prognosis of hepatocellular tial adult liver explants with cirrhosis. Semin Liver Dis. Wanless IR. Terminology of nodular hepatocellular lesions. Burroughs AK, et al. Clinical management of hepatocellular Kojiro M, Roskams T.

Early hepatocellular carcinoma and carcinoma.

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European Association for the Study of the Liver. Dig Liver Dis. Suriawinata A, Thung SN.

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International Concensus Group for Hepatocellular Neoplasia. Morenghi E, et al. Diagnostic value of HSP70, glypican 3, and Pathologic diagnosis of early hepatocellular carcinoma: Kojiro M.

Diagnostic discrepancy of early hepatocellular M, et al. A molecular signature to discriminate dysplastic carcinoma between Japan and West. Hepatol Res. Wu JT. Ann Clin Lab Sci. Role of alpha-fetoprotein in AFP level, and histologic grade. Int Surg. Llovet JM, Bruix J. Molecular targeted therapies in hepato- monitoring or both? Future Oncol. Molecular targets for al.

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Aliment trials. Pharmacol Ther. Thomas M. Molecular targeted therapy for hepatocellular Screening for hepatocellular carcinoma. International N, et al. Simplified staging for hepatocellular carcinoma. J Clin Estimates of global cancer Zender L, Kubicka S.

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