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Such instances include evaluating the impact of public policy changes, educational interventions or large scale health interventions. The primary drawback of quasi-experimental designs is that they cannot eliminate the possibility of confounding bias, which can hinder one's ability to draw causal inferences. This drawback is often used to discount quasi-experimental results. However, such bias can be controlled for using various statistical techniques such as multiple regression, if one can identify and measure the confounding variable s.

Such techniques can be used to model and partial out the effects of confounding variables techniques, thereby improving the accuracy of the results obtained from quasi-experiments. Moreover, the developing use of propensity score matching to match participants on variables important to the treatment selection process can also improve the accuracy of quasi-experimental results. In fact, data derived from quasi-experimental analyses has been shown to closely match experimental data in certain cases, even when different criteria were used.

On their own, quasi-experimental designs do not allow one to make definitive causal inferences; however, they provide necessary and valuable information that cannot be obtained by experimental methods alone. Researchers, especially those interested in investigating applied research questions, should move beyond the traditional experimental design and avail themselves of the possibilities inherent in quasi-experimental designs.

Quasi-experiments are commonly used in social sciences , public health , education , and policy analysis , especially when it is not practical or reasonable to randomize study participants to the treatment condition.

As an example, suppose we divide households into two categories: Households in which the parents spank their children, and households in which the parents do not spank their children. We can run a linear regression to determine if there is a positive correlation between parents' spanking and their children's aggressive behavior.

However, to simply randomize parents to spank or to not spank their children may not be practical or ethical, because some parents may believe it is morally wrong to spank their children and refuse to participate. Some authors distinguish between a natural experiment and a "quasi-experiment". Quasi-experiments have outcome measures, treatments, and experimental units, but do not use random assignment. Quasi-experiments are often the design that most people choose over true experiments.

The main reason is that they can usually be conducted while true experiments can not always be.

Quasi-experiments are interesting because they bring in features from both experimental and non experimental designs. Measured variables can be brought in, as well as manipulated variables.

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