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He had deliberately infected them with a virus to test whether each ailing microbe soldiered on alone or communicated with its allies to fight the attack. But when he and his team at the Weizmann Institute of Science in Rehovot, Israel, looked into the contents of their flasks, they saw something completely unexpected: the bacteria were silent, and it was the viruses that were chattering away, passing notes to each other in a molecular language only they could understand. They were deciding together when to lie low in the host cell and when to replicate and burst out, in search of new victims. Viruses that infect bacteria — spiky lollipop-like creatures known as bacteriophages or phages — have surveillance mechanisms that bring them intel on whether to stay dormant or attack, depending on the availability of fresh victims. But researchers long thought these processes were passive; the phages seemed to just sit back and listen in, waiting for bacterial distress signals to reach fever pitch before taking action. Sorek and his colleagues had found phages actively discussing their choices. As the phages infect more cells, the message gets louder, signalling that uninfected hosts are becoming scarce.
Instead, the hot spot to aim for is the upper tip where the protective hood is. To give her rubdown a raunchy edge, she can move her fingers in small circles, pressing down to stimulate the receptive nerve endings wall-to-wall on this part of the body. SPIRAL He can use his tongue to trace tiny, tantalizing circles in the center of her palm, in a gradual, oh-so-slowly widening motion.
But lifting her leg and leaning back to arch her back slightly turns this into a pose anyone can do—and has the happy side effect of pressing his pelvic bone against her clitoris with every thrust.
She can use her power to allow him to climax or withhold stimulation for a tortuous minute or two. To keep the action out of the emergency room, she should soften her skin by taking a warm shower before he starts and trim her tresses with nail scissors. A dab of hypoallergenic cream after will soothe things and get the sparks flying.
In the ancient practice of reflexology, certain pressure points in the feet can set off a full- body meltdown when stimulated. ON THE BENCH This elevated take on the wheelbarrow actually minimizes the amount of brute strength the move usually calls for, so both he and she can ride it out for as long as it takes. She can mix pleasure and pain by alternating between little hits and light taps with the tip from toes to chest, skimming—but not quite touching—his package, teasing him into a frenzy until he begs for mercy.
If she leans forward, she can take the controls and give him a wild ride. Slipping in a few smooches midcanoodle will intensify the connection, especially if they mimic sex play— hard and horny lipsmackers when the action is intense, and soft, romantic kisses when the love play starts slowing down.
For full impact, she can arch her back to suck him in even more. The relatively denser muscle mass in this area means that he wants her to push his tush with loads of lip pressure.
Pressing about one-third of the way down from the middle toe can cause energy to travel up the legs to the pelvis and make her feel hot to trot. Using his thumb and forefinger to pull gently, twist, and then rub below her toes will work faster than a Dirty Martini to get her to kick back and chill.
A racy rubdown can be just what the doctor ordered to romantically reconnect. It requires very little effort and time but delivers on thrills—making it ideal for a quick lunchtime tryst. Resting her hands on the back of a chair will take some of the pressure off her legs without losing momentum. Much more sensual and romantic is for him to pour the oil into his hands first, rub them together to warm things up, and then gently cup them around each breast, massaging upward toward the nipples.
Warning: The results are guaranteed to burn a hole in the bedsheets.
Seductively whispering, using a throaty purr, or playing around with different accents will keep the action bawdy instead of blushing. If she has good balance, she can use her leg to lock and load his head into position when he hits one of her high notes. A pair of nipple clamps will turn a blow job into a whoa job.
RUB A DUB DUB The key difference between an oh-your-poor-throbbing-feet massage and an ooh-la-la erotic foot rub is the pressure used— to give things a titillating tingle, lovers should skip the soft strokes and squeeze hard on the big toe and the sides and heel of each foot. Sex on a kitchen table is fast, frothy, and fabulous—especially when he stirs her legs to create even more friction. The secret recipe? He should penetrate her before she lifts her legs. To make things more intense, she can push her legs together, practically guaranteeing endless pleasure and pressure on her clit.
He may not be able to wait until she finishes before jumping in on the action. THE PUSH Pleasure will be her mission when she uses her hands to lightly press her legs down, causing her pelvis to grind deliciously against his.
So while making out and touching each other, lovers should take time to suck on bits like the fingers to give a taste of the mouth moves planned for below the belt. Using the desk chair helps her ease up and move around in new motions or adjust her position now and then without draining him.
Bonus: Chocolate contains the chemical phenylethylamine PEA , which can turn an orgasm into an especially rich and tasty treat. This molecular snooping occurs naturally in phages that infect the bacterium responsible for cholera, Vibrio cholerae. The viruses in effect became programmable assassins that could be made to kill off any bacterium — at will and on demand.
For the greater good Some viral cooperation seems to verge on altruism. Two independent groups reported last year that some phages act selflessly to overcome the viral countermeasures of Pseudomonas bacteria 10 , The first wave of viruses attacked the cells, killing themselves but also weakening the bacteria. The initial bombardment paved the way for others to conquer the microbial foe.
In follow-up work, Westra and his postdoc Anne Chevallereau demonstrated how phages lacking these anti-CRISPR proteins can exploit the cooperative offerings of others that do To Westra, that shows the potentially far-reaching consequences of altruistic behaviours among viruses. Take vesicular stomatitis virus VSV , which mainly infects farm animals, but can cause a flu-like illness in humans, too.
No one is sure yet how this cooperative evasion is happening, but the work highlights how crucial altruism can be for the success of VSV.
That could help scientists to beat the virus in farm animals, and optimize it for use in vaccines and therapeutics. Other instances of collective action are widespread among disease-causing viruses.
In poliovirus, for example, multiple genetically distinct viral strains can clump together to swap gene products and enhance their human-cell-killing potential And two strains of influenza — one that excels at cell entry, the other at cell exit — grow better when maintained in cell culture together than when kept apart And, Altan-Bonnet and her colleagues have shown, the particles become more infectious to mice when they are inside these cooperative clusters than when going it alone Many other pathogenic viruses — including those responsible for Zika, hepatitis, chickenpox, norovirus and the common cold — are now known to transmit themselves through these vesicles, too.
Several groups are testing phages as a treatment for bacterial infections — and knowing more about how they converse with each other could help to refine such therapies, which have a long history in medicine but are only just starting to be manipulated for therapeutic gain.
Engage the phage Last month, for instance, researchers described the first successful clinical use of genetically engineered phages to tackle a drug-resistant bacterial infection Like this document? Why not share! Embed Size px. Start on. Show related SlideShares at end. WordPress Shortcode. Full Name Comment goes here.
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